Berberine is a natural food supplement produced by certain plants. It is useful for regulating the metabolism of sugars and helps to maintain its weight. It also facilitates the activation of AMPK, which plays a crucial role in energy balance.
- Activation of AMPK and maintenance of energy homeostasis
- Type 2 diabetes
- Vascular protection
- Neurological injuries
- Bowel inflammation and leaky bowel
Berberine is a natural substance produced by certain plants Berberine has been used for thousands of years in Chinese and Ayurvedic medicine because of its antifungal, antibacterial, anti-inflammatory and immunostimulant effects. Recent studies have shown spectacular effects in metabolic and cardiovascular diseases, and its crucial role in activating a key enzyme involved in metabolism: AMPK.
1) AMPK (Adenosine Mono-Phosphate Kinase): is a phosphokinase which is present in many tissues and plays a vital role in energy homeostasis. AMPK is activated by Berberine and has multiple effects:
- stimulates oxidation of fatty acids in the liver,
- inhibits synthesis of cholesterol and triglycerides,
- modulates secretion of insulin by beta cells in the pancreas,
- normalises energy metabolism,
- regulates food intake and tissue sensitivity to insulin.
2) Berberine and type 2 diabètes: By activating AMPK, berberine increases expression of the gene for GLUT-4, a glucose transporter in muscle and fat cells, facilitates intracellular glucose transport and can lower plasma glucose levels by improving insulin sensitivity.
Berberine has been studied as an adjuvant in type 2 diabetes, with equivalent and sometimes superior results to those obtained with metformin. A recent study carried out in 116 patients with type 2 diabetes who were randomised to receive 1 g of berberine or placebo daily for three months showed a reduction in their glucose parameters: their HbA1c fell from 7.5% to 6.6% and their fasting plasma glucose fell from 126 to 100.8 mg/dl.
3) Berberine and dyslipidaemia: By inhibiting the activity of acetyl coenzyme A carboxylase, Berberine inhibits synthesis of fatty acids and reduces the level of circulating lipids in the blood:
- reduction in total cholesterol (-23.5 mg/dl),
- reduction in LDL-C (-25 mg/dl),
- reduction in triglycerides (-44 mg/dl),
- increase in HDL-C level (2 mg/dl).
4) Berberine and vascular protection: The activation of AMPK by Berberine accounts for its vascular protective effects, due to its positive impact on endothelial dysfunction which is the underlying cause of atherosclerosis.
5) Berberine and neurology: Berberine protects neurons and increases noradrenaline and serotonin levels while reducing dopamine, which is useful in treatment of depression, bipolar disorders and schizophrenia. Studies have shown that it has a beneficial effect on the development and progression of Alzheimer’s disease by inhibiting cholinesterase.
6) Berberine and the intestines: Berberine protects the intestinal epithelium, which has consequences in leaky gut syndrome, colitis and food allergies.
7) Berberine and cancer: A number of studies have shown that Berberine inhibits the growth of many cancers affecting the prostate, breast, pancreas, mouth, liver, bladder, colon, brain, thyroid and cervix, as well as leukaemias.
8) Berberine and Zinc excess (Inflammation): Berberine (500 mg three times daily for 6 weeks) can correct all cases of excess zinc measured using the oligoscan (an appliance that makes it possible to measure deficiencies or excess levels of vitamins, minerals and heavy metals). From a medical point of view it is recognised that zinc excess may be a sign of (sub)clinical inflammation and/or linked to non-alcoholic hepatosteatosis, sometimes accompanied by high levels of copper. Non-alcoholic hepatosteatosis is found in people who drink little or no alcohol but still have certain liver disorders. It tends to occur in people who are overweight and have diabetes or who have high levels of cholesterol and triglycerides.
Take three gel capsules daily for at least 6 weeks. To obtain the fullest effect, Berberine must be taken at a dose of 1500 mg per day.
Berberis Aristata (Indian barberry) 1000 mg – Microcrystalline cellulose – Silicon dioxide – Magnesium stearate – Plant-based gel capsule shell – Total net weight: 1466 mg per gel capsule.
Bottle containing 60 gel capsules.
This nutritional supplement can be combined with all other medicines or other nutritional supplements. It causes no side-effects and can be recommended to everyone.
- 60 comp.
- Berberis Aristata 1000 mg – Microcrystalline cellulose – Silicon dioxide – Magnesium stearate – Plant-based gel capsule shell.